Sign Out
Too large doses mainly cause hypotension, dizziness and vertigo, possibly also syncope. In most cases a dose reduction or temporary discontinuation of treatment is sufficient.
Ingestion of a larger quantity of the drug may lead to hypotension.
Measures: The patient should be placed in a supine position with the head lowered and legs slightly elevated. Induction of vomiting is not recommended. Other measures to eliminate the unabsorbed drug from the gastrointestinal tract should be employed (gastric lavage, activated charcoal, laxative).
Treatment is symptomatic and with α-adrenoceptor agonists, e.g. noradrenaline.
Hemodialysis is ineffective in the removal of the drug because doxazosin is almost completely bound to plasma proteins.
